The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth

A randomly generated action RPG shooter with heavy roguelike elements. Each playthrough is unique.

Nicalis Nicalis Hard

Released: 2014 Price: $14.99 ⭐ Overwhelmingly Positive (97%) Difficulty: Hard Official Website →

Platforms: PCPS4PS5Xbox OneNintendo SwitchMobile

Guides for The Binding of Isaac: Rebirth

Beginner Guides • The Binding of Isaac: Rebirth

Binding of Isaac: How to Unlock All Characters

A complete guide to unlocking every character in The Binding of Isaac: Rebirth and all its DLC.

Jun 7, 2026 1 min read

Build Guides • The Binding of Isaac: Rebirth

Binding of Isaac: Item Tier List & Synergies

Every major item ranked. Learn which items transform your run and which are traps in The Binding of Isaac.

Jun 11, 2026 1 min read

Advanced Strategies • The Binding of Isaac: Rebirth

Binding of Isaac: All Tainted Characters Guide

Unlock and master all Tainted characters in Repentance. Includes strategies for the Beast path and Home route.

Jun 10, 2026 1 min read

Frequently Asked Questions

What should a beginner know in Binding of Isaac?

Prioritize learning bullet hell movement over tanking damage. Watch for Devil Room and Angel Room entry requirements — avoid red heart damage to increase chances. Boss Rush and Hush unlocks are time-gated per floor.

How do I unlock new characters in Binding of Isaac?

Most characters unlock through specific in-game events. For example: Lazarus requires 4 Soul Hearts in a run, Eve requires 2 consecutive floors without taking damage. Complete specific challenges to unlock Bethany and Jacob & Esau.